Synthesis of 4,6-disubstituted 2-(4-morpholinyl)pyrimidines by cross-coupling reactions using triorganoindium compounds.
Identifieur interne : 000A14 ( Main/Exploration ); précédent : 000A13; suivant : 000A15Synthesis of 4,6-disubstituted 2-(4-morpholinyl)pyrimidines by cross-coupling reactions using triorganoindium compounds.
Auteurs : RBID : pubmed:23080018English descriptors
- KwdEn :
- MESH :
- chemical , chemical synthesis : Pyrimidines.
- chemical , chemistry : Indium, Organometallic Compounds, Palladium, Pyrimidines.
- Chemistry Techniques, Synthetic, Substrate Specificity.
Abstract
4,6-Disubstituted-2-(4-morpholinyl)pyrimidines, an important class of bioactive compounds, have been synthesized from 4,6-dichloro-2-(4-morpholinyl)pyrimidine by selective and sequential palladium-catalyzed cross-coupling reactions using triorganoindium reagents. This methodology, being efficient and versatile, allowed the synthesis of a variety of non-symmetrical pyrimidines functionalized at C-4 and C-6 positions.
DOI: 10.1039/c2ob26398j
PubMed: 23080018
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Le document en format XML
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<author><name sortKey="Mart Nez, M Montserrat" uniqKey="Mart Nez M">M Montserrat Martínez</name>
<affiliation wicri:level="1"><nlm:affiliation>Departamento de Química Fundamental, Universidade da Coruña, E-15071 A Coruña, Spain. mmartinezc@udc.es</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departamento de Química Fundamental, Universidade da Coruña, E-15071 A Coruña</wicri:regionArea>
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<author><name sortKey="Perez Caaveiro, Cristina" uniqKey="Perez Caaveiro C">Cristina Pérez-Caaveiro</name>
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<author><name sortKey="Pe A L Pez, Miguel" uniqKey="Pe A L Pez M">Miguel Peña-López</name>
</author>
<author><name sortKey="Sarandeses, Luis A" uniqKey="Sarandeses L">Luis A Sarandeses</name>
</author>
<author><name sortKey="Perez Sestelo, Jose" uniqKey="Perez Sestelo J">José Pérez Sestelo</name>
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<publicationStmt><date when="2012">2012</date>
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<term>Indium (chemistry)</term>
<term>Organometallic Compounds (chemistry)</term>
<term>Palladium (chemistry)</term>
<term>Pyrimidines (chemical synthesis)</term>
<term>Pyrimidines (chemistry)</term>
<term>Substrate Specificity</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Indium</term>
<term>Organometallic Compounds</term>
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<front><div type="abstract" xml:lang="en">4,6-Disubstituted-2-(4-morpholinyl)pyrimidines, an important class of bioactive compounds, have been synthesized from 4,6-dichloro-2-(4-morpholinyl)pyrimidine by selective and sequential palladium-catalyzed cross-coupling reactions using triorganoindium reagents. This methodology, being efficient and versatile, allowed the synthesis of a variety of non-symmetrical pyrimidines functionalized at C-4 and C-6 positions.</div>
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<Title>Organic & biomolecular chemistry</Title>
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<Abstract><AbstractText>4,6-Disubstituted-2-(4-morpholinyl)pyrimidines, an important class of bioactive compounds, have been synthesized from 4,6-dichloro-2-(4-morpholinyl)pyrimidine by selective and sequential palladium-catalyzed cross-coupling reactions using triorganoindium reagents. This methodology, being efficient and versatile, allowed the synthesis of a variety of non-symmetrical pyrimidines functionalized at C-4 and C-6 positions.</AbstractText>
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